Resins guanidine-functionalized

VII. RESINS AND LINKERS FOR GENERATION OF SULFONAMIDE, UREA, AND GUANIDINE FUNCTIONS... 

A quaternary ammonium hydroxide ion exchange resin 6 was shown to sequester phenols, hydroxypyrazoles, and other weakly acidic heterocycles.25 The sequestered nucleophiles could also be used as polymer-supported reactants. Similarly, the guanidine-functionalized resin 7 was also shown to be a useful capture agent for weakly acidic nucleophiles, including phenols and cyclic iV-acyl sulfonamides.26... 

Resins carrying the guanidine function have been patented as catalyst[128] for the preparation of organic disulfides and polysulfides11291 and the preparation of sulfonated olefins.[130]... 

Le Perchec, P., Abusio, M., Arretz, E. Resins having a primary amine or guanidine function and their preparation. 1996, WO 9721740. 

Resins of functional amine and guanidine functional groups were successfully used in sorption... 

Secondary amines can be cleaved from the resin either directly or after modification. Primary amines can be derivatized on the free N-H function and can therefore be modified to an array of products. Thus, ureas 81 [54], thioureas 80, guanidines 79, and carboxamides 82 were prepared in excellent yield (Scheme 6.1.17). 

Although selected polyamines, (VII), functionalized with guanidine, (VIII), were prepared by Dhal [4] for use in the treatment of gastrointestional disorders their application as a crosslinkable resin was also suggested by the author. 

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