Resin glycosides cytotoxicity

The synthesis of the disaccharide subunit 85 of tricolorin A, a cytotoxic resin glycoside isolated from lpomoea tricolor, provides a unique opportunity to compare the efficiency of an RCM-based macro cyclization reaction with that of a more conventional macrolactonization strategy. Furthermore, this specific target molecule challenges the compatibility of the catalysts with various functional groups. 

The route for the cytotoxic ipomoeassin resin glycosides relied on the use of compound 256 as a new cinnamic acid surrogate with its trisubstituted double bond and meets the requirement of being hydrogenation resistant in the presence... 

The cytotoxic potential of several resin glycosides has been evaluated against mammalian cancer cultured cell lines. For tricolorin A (106), the most potent cytotoxic activity (ED q 2.2 pg/cm ) was observed with human breast cancer and... 

A scientific revival of and a new interest in resin glycosides caused by the discovery of novel biological effects, e.g., antibacterial, cytotoxic, phytotoxic activities, could be observed during the last two decades. This development has stimulated again phytochemical research on these compounds. 

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