Residues, in enzyme activity

In this chapter, we discuss examples of heterogeneous catalysts inspired by the activity/selectivity and mechanism of enzymes, with a particular focus on how multiple surface functionahties can act cooperatively to perform the catalytic reaction such as they do in an enzymatic active site. The spatial positioning of identical or disparate functional groups is given attention, since simulating the precise arrangement of residues in enzyme active sites is one of the most important challenges in this field [1]. 

F igure 6.7. Proposed mechanism of action of vigabatrin (8) (afterRef 175). B, base in enzyme active site Nu, nucleophilic residue in enzyme active site. 

Bartlett GJ, Porter CT, Borkakoti N, Thornton JM (2002) Analysis of catalytic residues in enzyme active sites. J Mol Biol 324(1) 105-121... 

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