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Renal effects oxcarbazepine

Oxcarbazepine is completely absorbed, and food has no effect on its absorption. Unlike CBZ, it does not cause autoinduction of its own metabolism. The metabolism of oxcarbazepine is different from that of CBZ. Oxcarbazepine is reduced by cytosolic enzymes to MHD before its O-glucuronidation. More than 95% of its oral dose is excreted as conjugated metabolites, with approximately 4% of the drug converted to inactive 10,11-dihydroxy CBZ. Unlike CBZ, no epoxide nor aromatic hydroxylation metabolites are formed. The half-life is 2 hours for oxcarbazepine and 9 hours for the active 10-monohydroxy metabolite. In patients with impaired renal function, the half-life for MHD is prolonged to 19 hours, with a doubling in its area under the plasma concentration curve. Peak plasma concentration following an oral dose occurs at approximately 4.5 hours. [Pg.778]


See other pages where Renal effects oxcarbazepine is mentioned: [Pg.244]    [Pg.244]    [Pg.499]    [Pg.500]    [Pg.162]    [Pg.162]    [Pg.274]    [Pg.281]    [Pg.2647]    [Pg.327]    [Pg.244]    [Pg.778]    [Pg.263]   
See also in sourсe #XX -- [ Pg.247 ]




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Oxcarbazepine

Renal effects

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