Removal of Butoxycarbonyl Protective Group

The tcrt-butoxycarbonyl (BOC) group is often used for the protection of amino, hydroxy, and sulfhydryl groups. This kind of protection is usual in the chemistry of amino acids and peptide synthesis. 

the method has been worked out to remove the tcrt-butoxycarbonyl group that protects amines, alcohols, or thiols under neutral conditions rather than the conventional strongly acidic 

The catalytic effects and versatility of cerinm(IV) ammonium nitrate as a single-electron oxidant were recently reviewed (Nair and Deepthi 2007, Maulide et al. 2007). However, it should be kept in mind that this oxidative reagent is very powerful and some sensitive fnnctions are not compatible with it. Particularly, some amines are at least as easily oxidizable as the starting molecule bearing the protected group. Anodic oxidation was proposed as a usefnl alternative (De Lamo Martin et al. 2005). 

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