Remote chiral groups, optically active

Attempts to address the difficulty associated with the distance of the chirality in the Pd ligand to the site of C—C bond formation have been most fruitful. New chiral phosphine ligands containing an optically active functional group remote from the phosphines have been very effective, providing optical yields up to 52% in the case where the new chiral center is one carbon removed from the allyl ligand437 (c/. 10% optical parity obtained previously 434 equation 355). 

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