Relict mitochondrion

Preliminary evidence of a mitosome (relict mitochondrion) in Cryptosporidium was provided by an electron microscopic study that revealed the... 

Haresh K, Suresh K, Khairul Anus A, Saminathan S (1999) Isolate resistance of Blastocystis hominis to metronidazole. Trop Med Int Health 4 274-277 Inui H, Ono K, Miyatake K, Nakano Y, Kitaoka S (1987) Purification and characterization of pyruvate NADP+ oxidoreductase in Euglena gracilis. J Biol Chem 262 9130-9135 Keithly JS, Langreth SG, Buttle KF, Mannella CA (2005) Electron tomographic and ultra-structural analysis of the Cryptosporidium parvum relict mitochondrion, its associated membranes, and organelles. J Eukaryot Microbiol 52 132-140 Kurland CG, Andersson SGE (2000) Origin and evolution of the mitochondrial proteome. Micro Mol Biol Rev 64 786-820... 

An unusual and most likely cytosolic FeS enzyme of C. parvum is PNO, which consists of an N-terminal PFO domain followed by a C-terminal CPR (Rotte et al. 2001). Unlike the PNO of E. gracilis, which is targeted into mitochondria, the PNO of Cryptosporidium does not possess an N-terminal targeting extension and its presence in a relict mitochondrion is therefore unlikely. 

Keithly JS, Langreth SG, Buttle KF, Mannella CA (2005) Electron tomographic and ultrastruc-tural analysis of the Cryptosporidium parvum relict mitochondrion, its associated membranes and organelles. J Eukaryot Microbiol 52 132-140 Knight J (2004) Giardia not so special, after all Nature 429 236-237... 

---