Relative dynamic range definition

Figure 7.6. (a) Definitions of success rate and relative dynamic range, (b) Model of a proteomics experiment. (See color insert.)... 

Figure 1-13 illustrates the definition of the dynamic range of an analytical method, which extends from the lowest concentration at which quantitative measurements can be made (limit of quantitation, or LOO) to the concentration at which the calibration curve departs from linearity by a specified amount (limit of linearity, or LOL). Usually, a deviation of SSI. from linearity is considered the upper limit. Deviations from linearity are common at high concentrations because of nonideal detector responses or chemical effects. The lower limit of quantitative measurements is generally taken to be equal to ton times the standard deviation of repetitive measurements on a blank, or 10j . At this point, the relative standard deviation is about 3(1% and decreases rapidly as concentrations become larger. 

---