Rejection early diagnosis

In transplantation, levels of HA are often used in the early diagnosis of organ rejection. Liver and kidney are the two major organs involved in the final steps of total-body HA catabolism. When arteries to kidneys or liver are ligated, the circulating levels of HA increase immediately [45]. The HA concentration in the circulation of cancer patients is also often elevated [46]. 

Acute rejection occurs within weeks to months following transplantation and involves humoral (antibody) and cell-mediated induced cytotoxicity. Damage may be reversed with early diagnosis and more aggressive immunosuppressive therapy. 

The key to managing rejection is early diagnosis, before myocyte necrosis and stimulation of vascular endothelial cell proliferation. Rapid diagnosis allows immediate modification of the recipient s immunosuppressive therapy. 

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