Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Regulation by HIFs

Responses to low oxygen tension in tissues (hypoxia) are important to all aerobic organisms.464/467a d In mammals transcription of hypoxia-responsive genes is regulated by hypoxia inducible factors HIF-1 and... [Pg.1636]

HIF-la expression and activity are also regulated by phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) signal transduction pathways (Zhong et al. 2000 Semenza 2002). [Pg.308]

These results dramatically lower free ATP levels in HIF-la-deficient hypoxic cells (Seagraves et al., 2001). It is interesting to see that this switch of energy metabolism is regulated by one transcription factor HIF-la, the primary regulator of oxygen homeostasis, because HlF-la deficiency reduces energy metabolism. [Pg.239]

See other pages where Regulation by HIFs is mentioned: [Pg.131]    [Pg.727]    [Pg.49]    [Pg.52]    [Pg.525]    [Pg.540]    [Pg.3]    [Pg.144]    [Pg.94]    [Pg.270]    [Pg.131]    [Pg.727]    [Pg.49]    [Pg.52]    [Pg.525]    [Pg.540]    [Pg.3]    [Pg.144]    [Pg.94]    [Pg.270]    [Pg.262]    [Pg.285]    [Pg.125]    [Pg.125]    [Pg.335]    [Pg.335]    [Pg.719]    [Pg.69]    [Pg.284]    [Pg.308]    [Pg.318]    [Pg.346]    [Pg.133]    [Pg.133]    [Pg.134]    [Pg.134]    [Pg.144]    [Pg.230]    [Pg.731]    [Pg.448]    [Pg.375]    [Pg.275]    [Pg.276]    [Pg.277]    [Pg.277]    [Pg.278]    [Pg.280]    [Pg.295]    [Pg.48]    [Pg.50]   
See also in sourсe #XX -- [ Pg.3 , Pg.144 ]



SEARCH



HIF regulation

© 2024 chempedia.info