Regulation by Binding of Effector Molecules

The activity of eucaryotic transcriptional activators can be regulated by the binding of low molecular weight effectors, as well as by the binding of inhibitor proteins (see 1.3.2.3). The most significant example for transcriptional activators regulated by low molecular weight effectors are the nuclear receptors, which will be discussed in more detail in chapter 4. [Pg.59]

In this system, cognate hormones act as positive regulating effectors. The transcription regulating activity of nuclear receptors can also be negatively influenced by specific inhibitor proteins. These proteins are characterized as repressors. [Pg.59]