Regioselective direct arylations

Scheme 9.42 Palladium-catalyzed regioselective direct arylation of the indolizine 148...

Recent Advances in the C2 and C3 Regioselective Direct Arylation of Indoles... 

Reactions of indoles with metal-bound carbenoids 13AHC(110)43. Recent advances in the C2 and C3 regioselective direct arylation of indoles 12AHC(105)309. 

A comparable concept was applied in 1998 to rhodium-catalyzed oxidative direct arylations, which employed organometaUic compounds for regioselective direct arylations (Scheme 1.38) [128]. 

Recently, catalytic amounts of inexpensive Cul were employed for regioselective direct arylations of 1,2,3-triazoles (Scheme 9.42) [58]. 

Regioselective direct arylations are difficult to achieve because the arene reagents often contain several inequivalent C-H bonds that can react with the metal center at similar rates. Several approaches have been investigated to address tliis challenge. In some cases the reactions have been conducted intramolecularly, while in other cases the reactions have... 

Scheme 17.27 C3- and C4-regioselective direct arylation of pyridine with aryl halides.

Regioselective Direct Arylation of Thiophenes Using Catalyst Control. A cationic Ir-catalyzed direct arylation of electron-rich thiophenes with iodoarenes was disclosed (eq 11). ... 

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