Regioselective chemical synthesis

The combined use of enzymatic and chemical methods under the so-called chemoenzymatic synthesis offers the flexibility of chemical synthesis and the high regioselectivity and stereoselectivity of enzyme-catalyzed reactions to achieve highly efficient synthesis of complex carbohydrates. Chemoenzymatic glycosylation is... 

Chemoenzymatic approach served as an alternative method for the synthesis of complex carbohydrate-containing molecules. The use of biosynthetic enzymes not only provides high regioselectivity and stereoselectivity for the formation of glycosidic bonds but also solves the problems of protection and deprotection steps required by chemical synthesis. The discovery of bacterial counterparts and the advance in bioengineering technology led to breakthroughs in complex carbohydrate synthesis. 

Chemical synthesis, limited by complex synthetic approaches using protection of the sugar hydroxyl groups in order to achieve regioselectivity, and more so stereoselective reactions... 

In chemical synthesis, particularly for pharmaceutical applications, they give highly stereo- and regioselective syntheses that often are impossible using dassical catalysts. Enzymatic reactions combined with enantio-resolution can generate en-antiopure materials with high yields [150]. Enzymes can be extremely enantioselec-... 

The chemical synthesis of carbohydrates is subject to a number of difficulties. First, to realize the regioselective reactions at a particular position of a sugar unit, the hydroxyl group at this position has to be distinguished from all other hydroxyl groups in the structure, while all these hydroxyl groups have similar properties. Additionally, when a sugar unit has one or more branches attached to it, several... 

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