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Regioselective arylations pivalic acid

The modified procedure involving pivalic acid has also been used to regioselectively arylate a pyridine iV-oxide at the a-position in the presence of an indolyl fragment (eq 8). ... [Pg.259]

Using a similar protocol involving pivalic acid as an additive, the palladium-catalyzed regioselective C6-arylation of 3-aminoimidazo[ l,2-a]pyrazine was accomplished (eq 25). The use of di-teTt-butyl(methyl)phosphonium tetrafluoroborate as a ligand provided the products of C6 and C2 arylation in a ratio of 49 1. Furthermore, the competitive C2 -H activation pathway was avoided by replacing di-fert-butyl(methyl)phosphonium tetrafluoroborate by triphenylphosphine. ... [Pg.263]

Regioselective arylation of substituted isoquinolines was also viable. Notably, by switching Irom pivalic acid to 2,2-dimethylhexanoic acid, less reactive pyridine substrates, such... [Pg.538]

See other pages where Regioselective arylations pivalic acid is mentioned: [Pg.48]    [Pg.287]    [Pg.433]    [Pg.120]    [Pg.258]    [Pg.538]    [Pg.604]    [Pg.683]    [Pg.353]   
See also in sourсe #XX -- [ Pg.538 , Pg.541 ]



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Arylations pivalic acid

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Pivalate

Pivalates

Pivalic acid

Regioselective arylations

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