Refractometry Sensing

ChG-based SPR detection has recently been evaluated [94-97]. The SPR peak position is extremely sensitive to refractive index variation in the sensing medium caused by presence of molecules, and the technique works by monitoring the SPR dip shift using Kretschmann angular interrogation geometry. A refractive index detection limit of 3 x 10 refractive index units (RIUs) was experimentally demonstrated in the ChG-based SPR sensing system [95]. 

Besides SPR and resonators, other glass device platforms potentially suitable for refractometry detection include inteferometers and waveguide Bragg gratings [109]. 

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In addition, typical methods of sensing are total internal reflection fluorescence or monitoring of fluorescence resonance energy transfer6,7. The second class is a direct optical detection principle which relies either on reflectometry or refractometry. The latter is connected to evanescent field... 

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