Reductive elimination INDEX

Process simplification and reduction of indexing steps by eliminating activation and purification processes... 

C. The Rheodyne Model 7010 injection valve, equipped with a 20-pl loop, was switched to injection at the apex of the sample band, as observed on the refractive index detector. The complex kinetics of the production of mono-, di-, and tri-brominated glycols is shown in Figure 14. Optimization of parameters such as the flow rate of acid resulted in a 15% reduction in batch cycle time and eliminated the need for manual analysis and intervention to obtain a desired endpoint composition. 

When the excimer lamp of 308 nm is used for the irradiation light source, the refractive index lowers from 1.70 to 1.63. With the mercury-arc lamp the refractive index lowers to 1.58. The larger reduction of the refractive index with the shorter wavelength light derives from the elimination of the side-chain phenyl group. 

The covariate analysis identified weight, sex, creatinine clearance, body mass index (BMI), and age as having an influence on PK parameters of NS2330 and/or Ml, respectively. The overall clearance of NS2330 is reduced by 20.5% in females compared to males and the NS2330 clearance which accounted for any elimination pathways except the formation of Ml from NS2330 (CLnon.met/F) is reduced in patients with a creatinine clearance lower than 62.5 ml/min ( 1.2% reduction per 1 ml/min reduction). The volume of distribution of NS2330 is influenced by body... 

The classical PCA is non-robust and sensitive to deviations of error distribution from the normal assumption, the PC directions being influenced by the presence of outlier(s). In PP PCA, the PC directions are determinated by the the inherent structure of the main body of the data. Using some robust projective index, the influence of the outliers is thus substantially reduced. The distorted appearance or misrepresentation of the projected data structure in the PC subspace caused by the presence of outlier(s) could be eliminated in PP PCA. This characteristic feature of PP PCA is essential for obtaining reliable results for exploratory data analysis, calibration and resolution in analytical chemometrics where PCA is used for dimension reduction. 

ABSTRACT We describe a method based on mass-orthogonal projections that can be used to eliminate the algebraic variables in the DAEs of index 2 of multibody system dynamics, reducing them to ODEs. A choice among the infinitely many ODE systems that describe the dynamics correctly is proposed. A reduction of the computational cost of linear algebra operations is described. We present DYNAMITE, a tool-kit based software for the simulation of multibody systems that implements the methods discussed, and illustrate its application to a low-voltage circuit breaker. 

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