Reduction with—cont

It has been recommended that the dosing interval of pentamidine be extended to 48 hours for patients with a GFR less than 10 ml/min [173] and that there is no need for dosing after hemo or peritoneal dialysis. However, Conte in his report [141], suggested that dose reduction of pentamidine for renal impairment is unnecessary and noted that while his patients had mild to moderate PCP, it remains unknown whether the pharmacokinetics of pentamidine might be altered in more severely ill patients. 

Figure 7 Mean infection scores of P. ctm nti cysts in homogenates of lung tissues in our four-day cyst reduction model (41). Immunosuppressed rats were allowed to develop heavy P. carinii infections, they were treated with LY303366 for up to 4 days, and the numbers of cysts in the lungs were counted microscopically. Treatment groups were A, animah receiving a single 10 mg IV dose 4 days prior to necropsy B, animals receiving a single 5 mg/kg IV dose 4 days prior and daily 5 mg/kg oral doses on days 1—4 prior to necropsy C, animals receiving daily oral doses on days 1-4 prior to necropsy. Infected control (Inf. cont.) animals received no therapy for P. carinii pneumonia.

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