Reduction through greater chemical accuracy, synthesis tree

SYNTHESIS TREE REDUCTION THROUGH GREATER CHEMICAL ACCURACY 

1 STERIC EFFECTS. A chemist predicts sterlc effects by evaluating the possible approach of a reagent to a three-dimensional model of the reacting molecule. SECS does the same 

ACS Symposium Series American Chemical Society Washington, DC, 1977. 

We developed a calculational model for this type of reaction to permit evaluation of steric accessibility and its inverse. congestion, on any type of molecular structure (see fig. 6).  

Using this model to predict the major product from ketone reductions, we found predictions correlate well with experiment (n = 34, = 0.924). We also found this model applicable to 

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