Reduction potential as a predictor of drug activation rates

4 Reduction potential as a predictor of drug activation rates 

Some of the flavoproteins which catalyse the reduction of bioreductive drugs show redox-controlled catalysis. The most important of these is probably NADPHxytochrome P-450 reductase, a one-electron donor [147]. At the simplest level, such proteins can be modelled by reduced flavin mononucleotide, FMNHa [148]. 

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