Reduction of diethyl isonitrosomalonate

Snyder and Smith prepared diethyl acetamidomalonate in 40% yield by reduction of diethyl isonitrosomalonate in ethanol over palladium on charcoal followed by direct acetylation of diethyl aminomalonate in the filtrate with acetic anhydride. Ghosh and Dutta used zinc dust instead of palladium. A modification using Raney nickel is described by Akabori et al. Shaw and Nolan reported a 98% yield by conversion of diethyl oximino-malonate-sodium acetate complex. [Pg.23]

Diethyl aminomalonate, from reduction of diethyl isonitrosomalonate, 40, 2 ... [Pg.111]

Diethyl acetylenedicarboxylate as di-eneophile, 40, 86,87 Diethylamine, condensation with tri-chloroacetyl chloride, 41, 21 Diethyl aminomalonate, from reduction of diethyl isonitrosomalonate, 40, 24... [Pg.58]

According to the submitters, reductions using as much as 0.3 mole of diethyl isonitrosomalonate were carried out. [Pg.25]

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