Reconstructed chromatogram from selective reaction monitoring

Figure 5.58 Reconstructed LC-MS-MS ion chromatograms for selected-reaction monitoring of methoxyfenozide using the m/z 367 to m/z 149 transition from the continual post-column infusion of a standard solution of analyte during the HPLC analysis of a...

Figure 5.67 Reconstructed ion chromatograms for Idoxifene and internal standard (ds-Idoxifene using LC-ToF-MS for (a) double-blank human plasma extract, (b) extract of blank human plasma containing internal standard (IS), and (c) control-blank human plasma spiked with Idoxifene at 5 gml , the LOQ of the method. Reprinted from 7. Chromatogr., B, 757, Comparison between liquid chromatography-time-of-flight mass spectrometry and selected-reaction monitoring liquid chromatography-mass spectrometry for quantitative determination of Idoxifene in human plasma , Zhang, H. and Henion, J., 151-159, Copyright (2001), with permission from Elsevier Science.

Selected reaction monitoring is illustrated in Figure 24-22. Trace a is the reconstructed total ion chromatogram of extract from an orange peel. To make the analysis... 

Figure 24-22 Selected reaction monitoring in gas chromatography-mass spectrometry, (a) Reconstructed total ion chromatogram of extract from orange peel with electron ionization, (b) Selected reaction monitoring with the precursor ion m/z 293 selected by mass filter Q1 in Figure 22-21 and product ion m/z 264 selected by mass filter Q3. The chromatogram is a graph of intensity at m/z 264 from Q3 versus time. [Courtesy Thermo Ftnnlgan GC ana GC/MS Division, San Jose. CA.J...

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