Receptors crystal structure

De Vos, A.M., Ultsch, M., Kossiakoff, A.A. Human growth hormone and extracellular domain of its receptor crystal structure of the complex. Science 255 306-312,... 

Armstrong, N. and Gouaux, E., Mechanisms for activation and antagonism of the AMPA-sensitive glutamate receptor crystal structures of the GluR2 ligand binding core, Neuron, 28, 165-181, 2000. 

Locher, K. P., Rees, B., Koebnik, R., Mitschler, A., Moulinier, L., Rosenbusch, J. P. and Moras, D. (1998). Transmembrane signaling across the ligand-gated FhuA receptor crystal structures of free and ferrichrome-bound states reveal allosteric changes, Cell, 95, 771-778. 

F. Fages, J.-P. Desvergne, H. Bouas-Laurent, J.-M. Lehn, J. P. Konopelski, P. Marsau, and Y. Barrans, Synthesis and fluorescence emission properties of a bis-anthracenyl macrotricyclic ditopic receptor. Crystal structure ofits dinuclear rubidium cryptate, J. Chem. Soc., Chem. Commun. 655(1990). 

Metal chelation has also been applied in studies of the structural-functional basis for seven-trans-membrane receptor activation. Using the (i2-adrenergic receptor as a model system, Filing el al. introduced several point mutations to form a metal binding site between trans-membrane helices III, VI and VII and showed that the receptor could be activated by metal ions alone or metal ions chelated by phenanthroline or bipyridine.1391 Based on a homology model built over the rhodopsin receptor crystal structure, helices III, VI and VII would have to move inwards to form a metal chelation site, suggesting that movement of these helices is critical for receptor activation. 

Thus, EcR LBD homology models based on vertebrate nuclear receptor crystal structures, although instructive for general architecture and residue replacement, are, owing to their low sequence identity, rather speculative when used for ligand docking or as tools for virtual screens [164],... 

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