Receptors and Their Endogenous Agonist, Anandamide

CANNABINOID RECEPTORS AND THEIR ENDOGENOUS AGONIST, ANANDAMIDE 

Analogous to the discovery of endogenous opiates, isolation of cannabinoid receptors provided the appropriate tool to isolate an endogenous cannabimimetic eicosanoid, anandamide, from porcine 

Evidence for an Interaction between the Cannabinoid-Anandamide System and Other Neuroreceptor Systems 

Anandamide and THC significantly increase serum levels of corticotrophin (ACTH) and corticosterone in a dose-dependent 

Note The cannabis plant has been cultivated for centuries both for the production of hemp fiber and for its presumed medicinal and psychoactive properties. The smoke from burning cannabis contains many chemicals, including 61 different cannabinoids that have been identified. One of these, A9-tetrahydrocannabinol (A9-THC), produces most of the characteristic 

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Axelrod, J. and Felder, C.C., Cannabinoid receptors and their endogenous agonist, anandamide, Neurochem. Res., 23, 575-581, 1998. 

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