Receptor-relevant subspace

Pearlman RS, Smith KM. Metric validation and the receptor-relevant subspace concept. / Chem Inf Comput Sci 1999 39 28-35. 

Pearlman and Smith have reported the receptor-relevant subspace concept [18], using ACE inhibitors as an example. They found that only 3 out of the 6 universal BCUT metrics were receptor-relevant , in that the actives clustered only in these 3 dimensions. These 3 metrics are then considered receptor-relevant and worthy of being constrained, while the other can be varied and not falsely constrained. 

Pearlman, R.S. and Smith, K.M. Metric Validation and the receptor-relevant subspace concept. J. Chem. Inf. Comput. Sci., 1999,39, 28-35. 

Pearlman RS, Smith KS (2002) Novel software tools for chemical diversity. 3D QSAR in drug design three-dimensional quantitative structure-activity relationships 2 339-353 Pearlman RS, Smith KM (1999) Metric validation and the receptor-relevant subspace concept. J Chem Inf Comput Sci 39 28-35... 

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