Rebound catalysis

The mechanism of cytochrome P450 catalysis is probably constant across the system. It is determined by the ability of a high valent formal (FeO) species to carry out one-electron oxidations through the abstraction of hydrogen atoms or electrons. The resultant substrate radical can then recombine with the newly created hydroxyl radical (oxygen rebound) to form the oxidized metabolite. Where a heteroatom is the (rich) source of the electron more than one product is possible. There can be direct recombination to yield the heteroatom oxide or radical relocalization within the... 

Alkyl hydroperoxides, manganese, ribonucleotide reductose, hydrogen peroxide, catalase activity, tetranuclear manganese, PSII, OEC, cumene, cumene hydroperoxide, biomimetic catalysis, bioinspired catalysis, C-H activation (hydrogen activation), oxygen activation, hydroperoxide decomposition, radicals (alkyl radicals and hydroperoxy radicals) and hydrogen rebound (rebound mechanisms). 

Catalysis by coordination compounds also plays an important role in the field because high valent Fe and Mn 0x0 complexes can abstract a hydrogen atom from a C-H bond, leading to fast rebound of the newly formed OH group to the C radical to give the alcohol (Eq. 12.24),... 

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