Reactivity of Ring Nitrogen Atoms

The 2-methyl derivative was prepared from perhydropyrido[l,2-c] pyrimidine-1,3-dione on treatment with diazomethane in aqueous methanol (56CB1642). The methoiodide was obtained from perhydropyrido[l,2-cjpyrimidine with methyl iodide (59CB637). 

The alkylation of 2-(substituted amino)-9,10-dimethoxy-6,7-dihydro-4H-pyrimido[6,l-a]isoquinolon-4-ones usually led to a mixture of 2-(disubstituted amino)-6,7-dihydro and 2-(substituted imino)-3-alkyl-2,3,6, 

Hydrolysis of 2-acetyl-l-[cyano(nitro)methylene]perhydropyrido[l,2-cjpyrimidine in boiling 5 N hydrochloric acid gave the 2-unsubstituted derivative [74JCS(P1)1611]. 

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Chapters 2 and 3, both authored by Wilhelm Flitsch (Federal Republic of Germany), deal, respectively, with the chemistry of the azaazulenes (not previously covered since 1958) and of hydrogenated porphyrins, a class of increasing importance in biochemical processes. The reactivity of ring-nitrogen atoms in azines toward electrophiles is covered by M. R. Grimmett (New Zealand) and B. R. T. Keene (England) in Chapter 4. 

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