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Reactive species isolation, from reversible

Wink et al. (1993b) demonstrated that NO (and/or reactive species formed from -NO autoxidation) inhibits CYP activity in both reversible and irreversible manners. Khatsenko et al. (1993) reported that the decrease in total microsomal CYP caused by endotoxin injection in rats is inhibited by coadministration of N°-nitro-L-arginine methyl ester (l-NAME), an inhibitor of NO synthase (NOS), indicating that the decrease in drug-metabolizing activity under inflammatory conditions is a result of endogenous -NO synthesis. Stadler etal. (1994) demonstrated a decrease in CYP activity and protein expression in vitro in isolated hepatocytes as a result of -NO synthesis. [Pg.279]

Isolation of the Reactive Species from Solution by Reversible Encapsulation... [Pg.86]

See other pages where Reactive species isolation, from reversible is mentioned: [Pg.684]    [Pg.110]    [Pg.110]    [Pg.942]    [Pg.125]    [Pg.684]    [Pg.875]    [Pg.292]    [Pg.696]    [Pg.103]    [Pg.487]    [Pg.142]    [Pg.268]    [Pg.39]    [Pg.187]    [Pg.259]    [Pg.608]    [Pg.268]    [Pg.83]    [Pg.53]    [Pg.77]    [Pg.167]    [Pg.16]    [Pg.17]    [Pg.332]    [Pg.263]    [Pg.35]    [Pg.161]    [Pg.201]   


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