Reactions of Alkylthiopyrazines

The dealkylation of alkylthiopyrazines to pyrazinethiones has been covered already (Section 6.1.1). Of the other possible reactions of alkylthiopyrazines, those represented in recent literature are discussed in the following subsections. 

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Minor reactions of alkylthiopyrazines are illustrated by the following examples ... 

Halogenopyrazines react with alkylthiolate ions to give alkylthiopyrazines, by replacement of one or, in some cases, two halogeno substituents the reaction is usually carried out at reflux or at elevated temperatures in sealed tubes. The following pyrazines have been prepared by these methods from the chloropyrazines unless otherwise specified 2-ethylthio and 2-isopropylthio (668a) 2-methyl-3-methylthio (735, 844,977) 2-methyl-5(and 6)-methylthio (735) 2,5-dimethyl-3-methyl(ethyl,... 

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