Reactions Mediated by Cyclodextrins

Department of Nanochemistry, Faculty of Engineering, Tokyo Polytechnic University, Atsugi, 

Molecular Encapsulation Organic Reactions in Constrained Systems Edited by Udo H. Brinker and Jean-Luc Mieusset 2010 John Wiley Sons, Ltd 

The complexation mode stoichiometries, conformations, and dynamics The possibility of simultaneous formation of complexes with different stoichiometries must also be considered. Cooperative binding, a bi-molecular process, has been observed, as well as the uni-molecular process, producing a 1 1 complex in either a head-to-tail (HT), tail-to-tail (TT) or head-to-head (HH) state. Moreover, a study of the fluorescence decay of a number of aniUnonaphthalene sulfonates in the presence of CD supported the view that a 1 1 complex can be present in several slightly different conformations. There are, in fact, various conformations and orientations of reactants as well as varying mobilities in reactant-CD complexes. 

Interactions The complexation is based on a combination of several intermolecular interactions depending on the solvent and the nature of the host and guest steric fit, van der Waals interactions, dispersive forces, dipole-dipole interactions, charge-transfer 

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The present review deals with a particular aspect of the chemistry of cyclodextrins the effects that they can have on organic reactions by virtue of their abilities to bind to many organic and inorganic species (Bender and Komiyama, 1978 Saenger, 1980 Szejtli, 1982). It is a considerable expansion of an earlier work (Tee, 1989) which first showed how the Kurz approach to transition state stabilization can be employed profitably in discussing reactions mediated by cyclodextrins. Most of the large amount of data that are analysed is collected in tables in the Appendix so as to avoid breaking up the discussion in the main text too frequently. 

NMR studies of cyclodextrin and cyclodextrin complexes 98CRV1755. Organic reactions mediated by cyclodextrins 98CRV2013. 

K. Takahashi, Reactions mediated by cyclodextrins, the chapter after next in this book. 

Reactions Mediated by Cyclodextrins 99 Table 4.1 The formation constants of various guests with trans- and c s-AzCD... 

Takahashi, K. "Organic Reactions Mediated by Cyclodextrins." Chem. Rev., 98,2013-2033 (1998). 

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