Reactions Leading to the Formation of Polycyclic Compounds

In a pioneering work, Curran et al. demonstrated the practicability of radical [4 -F 1 ] annulations with isonitriles for the synthesis of cyclopenta-fused quinolines, a structural motive constituent of camptopthecin family antitumor agents [152,153]. This reaction proved to be highly efficient and of unrivalled flexibility, enabling the preparation of an unprecedented number 

In a similar way, Zanardi and Nanni exploited [4 -i- I] annotations leading to the synthesis of a series ofbenzothieno[2,3-b]quinoxahnes ]160,161]. Add- 

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