Reactions, Intermolecular Complexation and other Features of Glycosides

In the field of sialic acids compound 58 has been derived by appropriate additions to the 2,3-ene and appears to be a potentially important sialylating agent giving almost 100% a-selectivity several appropriate disaccharides and trisaccharides were made. From the 3-deoxy-2-acetylthio derivative several S-alkyl thioglycosides have been made by treatment with the alkyl bromides in alkaline conditions. Synthesis of the thiocoumaryl a-glycosides 59 was effected to afTord potential fluorogenic substrates for sialidases.  

Certain thioxylosides are good substrates for a glycosyl transferase in vivo, and on oral administration to rats elicit a large increase in plasma concentrations of glycosaminoglycans. The same compounds have important anti-thrombotic activity in rats. 

Partial deacetylation of thioglycoside peracetates during synthesis has been reported above and many disaccharides and oligosaccharides mentioned in Chapters 3 and 4 have been made by use of such compounds. 

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