Reactions Initiated by the Knoevenagel Reaction

It consists in the condensation of aldehydes or ketones with active methylene compounds in the presence of a base [288]. The first organocatalytic enantiose-lective domino multicomponent reaction, which was developed by Barbas et al. 

Another four-component reaction initiated by a Knoevenagel condensation was reported by Xu et al. [297]. This process was catalyzed by simple i-proHne and 

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