Reaction with Low Molecular Weight Alcohols - the Fischer Glycoside Synthesis

2 Reaction with Low Molecular Weight Alcohols - the Fischer Glycoside Synthesis 

The acid used in the Fischer glycoside synthesis was originally HCl (which made the kinetic data reproducible only with difficulty, as in methanol HCl is slowly consumed to form methyl chloride). Nowadays, ion-exchange resins are used preparatively, whilst the data on 4- and 5-O-methylated glycosides were obtained with camphor sulfonic acid. 

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