Reaction polymer-supported reagent

A solid-phase Diels-Alder reaction that uses polymer-supported reagents has recently attracted considerable attention and its use is expanding rapidly. 

Using a more reactive polymer-supported reagent (polymer-supported-2-fluoropyridinium triflate, PS-FPT) gave the desired product, but the reaction at room temperature was very slow and complete conversions could rarely be observed, which of course represents a serious limitation as the unreacted hy-droxyamide would need to be removed in order to obtain the products in high... 

Polymer-supported reagents and other solid sequestering agents may be used to generate an array of 1,2,3,4-tetrasubstituted pyrrole derivatives using the Barton-Zard reaction as a key pyrrole formation reaction. Pure pyrroles are obtained without any chromatographic purification... 

Beilina F, Carpita A, Rossi R (2004) Palladium catalysts for the Suzuki Crosscoupling reaction an overview of recent advances. Synthesis 2419-2440 Bhattacharyya SJ (2000) Polymer-supported reagents and catalysts recent advances in synthetic applications. Comb Chem High Throughput Screening 3 65-92... 

Ley SV, Baxendale IR (2002b) New tools and concepts for modern organic synthesis. Nat Rev Drug Disc 1 573-586 Ley S V, Massi A (2000) J Comb Chem Polymer supported reagents in synthesis preparation of bicyclo[2.2.2]octane derivatives via tandem michael addition reactions and subsequent combinatorial decoration. 2 104—107 Ley SV, Schucht O, Thomas AW, Murray PJ (1999) Synthesis of the alkaloids ( )-oxomaritidine and ( )-epimaritidine using an orchestrated multi-step sequence of polymer supported reagents. J Chem Soc Perkin Trans 1 1251— 1252... 

Polymer-supported reagents differ from polymer-supported substrates in that the former mediate a reaction rather than becoming an integral part of the product. A major attribute of tethered reagents is that both the reagent and the reagent byproduct can be directly filtered away from solution-phase products. 

One research group has exploited the concept of polymer site-isolation in a multistep/one-chamber solution-phase synthesis in which all the reagents, catalysts, and downstream reactants required for a multistep synthesis were combined in one reaction chamber. For instance, a one-chamber/three-step synthesis of substituted acetophenones has been reported (Scheme 10).84 An a-phenethyl alcohol was introduced into a reaction chamber containing the polymer-supported reagents and reactants necessary to accomplish oxidation by polymer-supported pyridinium dichromate 60 bromination by the A-26 perbromide resin 61 and nucleophilic displacement by the A-26 phenoxide resin 62. Filtration afforded the... 

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