Reaction of Heterosubstituted Allylmetal Reagents with Electrophiles

3 Reaction of Heterosubstituted Allylmetal Reagents with Electrophiles 

An important regiochemical issue arises when functional groups are present on the olefinic moiety the electrophilic reagent can enter either the a- or the /3-position with respect to the substituent. 

The good 7-selectivity has been successfully applied in the first step of the synthesis of ( )- o-brevicomin.100 

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