Reaction information, printed sources

A limitation of printed databases is that they may become outdated once published, they are unable to incorporate new information on kinetic parameters. The combustion specific databases listed above were published in the period 1973 to 1994 the most recent [23] covers the literature through 1992. This implies that data on combustion related reactions published since 1992 are not considered in these evaluations, and for a number of significant reactions the recommendations may be misleading. This deficiency of printed databases is to some extent overcome by the electronic database [256] offered by National Institute of Standards and Technology (NIST). The NIST database,1 which is regularly updated, also references most of the expert evaluations listed above. The drawback of using these kinds of data compilations is that the user may have to perform some data evaluation, that is, choose between data from various sources. 

Information regarding adverse effects of medications is available from many sources and in multiple formats (i.e., print, CD-ROM, online). Table 25.7 lists selected sources of ADR information. To assist in ADR detection, evaluation, and management, critical data regarding adverse reactions are needed (Table 25.8). 

CCR contains 243000 reactions (1986-1994), and its annual growth is more than 30000 reactions, almost half of these being new synthetic methods. Sources for the database are about 350 Journals (before 1992, about 150) and US patents the printed CCR and the CD-ROM ChemPrep (see Section 3.2.11) are produced from only about 100 Journals. Besides the usual bibliographic information, full abstracts are also included in CCR (since 1991). Three of the 11 reactions from Goldsmith and Soria were retrieved from CCR. 

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