Reaction —cont ketones

Table 2.40 Asymmetric Aldol Reaction of Ketones and Aromatic Aldehydes —cont d...

Fig. 10.46 (cont.) Mechanistic possibilities for the 1,4-addition of a Gilman cuprate to an a,/Lunsatitrated ketone. Part 2 shows the formation of the CuR-containing enolate (I) and its further reaction with typical electrophiles. The fact that all intermediates of this 1,4-addition are chiral, but generated in racemic form should not be overlooked consequently, the same is true of the final products J, K and L. 

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