Rationale for mixture-based combinatorial libraries

patent has been issued covering nonnatural antisense structures in a combinatorial library format that claims the combinatorial library itself in an independent claim [89], The consequences of this type of claim and/or the likelihood this type of claim will be granted for heterocyclic libraries are unknown at this time. 

5 Rinnova, M. and Lebl, M., Coll. Czech. Chem. Commun, 61 (1996) 172. 

7 Chaiken, I. and Janda, K.D. (Eds.) Exploiting Molecular Diversity and Solid-Phase Synthesis, American Chemical Society, Washington, DC, U.S.A., 1996. 

8 Cortese, R. (Ed.) Combinatorial Libraries Synthesis, Screening, and Application Potential, Walter de Gruyter, Berlin, Germany, 1996. 

21 Safar, P., Stierandova, A. and Lebl, M., In Maia, H.L.S. (Ed.) Peptides 1994 (Proceedings of the 23rd European Peptide Symposium), ESCOM, Leiden, The Netherlands, 1995, pp. 471 172. 

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