Rationale for Infusion Therapy

The medicinal use of proteins and peptides, nevertheless, has imposed many challenging new problems on the pharmaceutical industry. In general, these molecules are difficult to stabilize as they often undergo a variety of physical and chemical transformations including precipitation, aggregation, 

Ulrike Bremer Pharmetrix, Inc., Menlo Park, California 94025. C. Russell Horres CyberRx, Inc., San Diego, CaBfomia 92130. MichaelL. Francoeur Phar- 

Protein Delivery Physical Systems, Sanders and Hendren, eds.. Plenum Press, New York, 1997. 

Pharmacokinetic Parameters and Reconunended Administration of Neupogen , Actimmune , and Pro1eukin  

Drug Administration Dose (Pg/kg) Plasma level (pg/ml) Volume of distribution Elimination half-life Clearance Recommended administration 

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