Rashes iloprost

A 71-year-old woman with systemic sclerosis took bosentan for digital ulceration that was unresponsive to intravenous iloprost, and after 6 weeks she developed a fever, a maculo-papular rash, and headache. She had raised aminotransferases and an eosinophilia. The symptoms and signs were in keeping with DRESS. Bosentan was immediately withdrawn and the symptoms rapidly resolved. 

Feito RM, Floristan U, de Lucas LR. A curious but non-serious local side effect of inhaled iloprost sudden linear erythematous facial rash. Clin Exp Dermatol 2009 34(8) el014. 

Skin A curious but non-serious local adverse reaction to iloprost, a linear erythematous facial rash, has been described in an 11-year-old boy with severe pulmonary hypertension associated with right ventricular failure, who was given iloprost by inhalation [32 ]. On one occasion, the child removed the mouthpiece and chamber lid and applied iloprost directly to his cheek. A few minutes later, he developed two erythematous linear skin lesions spreading over his face and neck, which resolved spontaneously within 3 days. 

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See also in sourсe #XX -- [ ]

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