Raphe nucleus serotonergic neurons

Raphe nucleus Serotonergic neurons metabolism in striatum Altar et al., 1994a... 

Lowry, CA, Odda, JE, Lightman, SL and Ingram, CD (2000) Corticotropin-releasing factor (CRF) increases the in vitro firing rates of serotonergic neurones in the rat dorsal raphe nucleus evidence for selective activation of a topographically organised mesolimbocortical system. J. Psychopharmacol. 14 (Suppl 2) All. 

Levine, E. S. Jacobs, B. L. (1992). Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus microiontophoretic studies in the awake cat. J. Neurosci. 12, 4037-44. 

Liu, R., Jolas, T. Aghajanian, G. (2000). Serotonin 5-HT(2) receptors activate local GABA inhibitory inputs to serotonergic neurons of the dorsal raphe nucleus. Brain Res. 873, 34-45. 

Wang, Q. P., Ochiai, H. Nakai, Y. (1992). GABAergic innervation of serotonergic neurons in the dorsal raphe nucleus of the rat studied by electron microscopy double immunostaining. Brain Res. Bull. 29, 943-8. 

Lesions of serotonergic neurons in laboratory animals have been reported by some, but not all, investigators to disrupt locomotor rhythms or to result in the loss of the daily rhythm of corticosterone. There is evidence that, in the hamster, the median raphe nucleus projects to the SCN whereas the dorsal raphe nucleus innervates the IGL furthermore, the serotonergic innervation to the SCN and not the IGL is necessary for the photic entrainment of locomotor activity [22]. It appears then, that the SCN circadian pacemaker or clock is modulated by stimulation of serotonergic receptors in the SCN and that serotonergic projections to the SCN may modulate the phase of the SCN in intact animals. 

Wang, R. Y., and Aghajanian, G. K. (1982) Correlative firing patterns of serotonergic neurons in rat dorsal raphe nucleus. J. Neurosci., 2 11-16. 

Kirby LG, Chou-Green JM, Davis K, Lucki I (1997) The effects of different stressors on extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid. Brain Res 760 218-230 Kirby LG, Rice KC, Valentino RJ (2000) Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus. Neuropsychopharmacology 22 148-162 Kozicz T, Yanaihara H, Arimura A (1998) Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J Comp Neurol 391 1-10 Lavicky J, Dunn AJ (1993) Corticotropin-releasing factor stimulates catecholamine release in hypothalamus and prefrontal cortex in freely moving rats as assessedby microdialysis. J Neurochem 60 602-612... 

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