Ramipril properties

Ramipril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive properties (2 to 5 mg p.o. daily), is used in the treatment of hypertension, either alone or in combination with thiazide diuretics (see also Eigure 24). 

M KCl were performed on the PCA 101 titrator. .. at 25 °C for amiodarone, metoprolol and ramipril and at 37 °C for atenolol. The pKa values of metoprolol, atenolol, and ramipril were determined in 0.15M KCl. For die extrapolation of the aqueous pKa of amiodarone, we used the Yasuda-Shedlovsky plot (4). Apparent pKa values (+ log [H2O]) in the medianol/O.lSM KCl mixtures at ratios between 47 and 71%(w/w) methanol were plotted against the inverse dielectric constant... and the pKa of the molecule in 100% aqueous solution was extrapolated by linear regression." surface H2O Ferreira J, Brasseur R, Chatelain P and Ruysschaest J, Properties of... 

Todd PA, Benfield P. Ramipril. A review of its pharmacolcgical properties and therapeutic efficacy in cardiovascular disorders. Drugs (1990) 39,110-35. 

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