Radula perrottetii

P. E-G are open-chain bisbibenzyls with linear linkages of the two bibenzyl units through an ether bridge. They are considered to be biogenetic precursors of cyclic bisbibenzyls (see riccardins and marchantins). In contrast, the P. A-D are prenylated bibenzyls. The occurrence of P. is limited to liverworts. P. E., isolated from Radula perrottetii (which also contains F and G) and other liverworts, is cytotoxic to KB cells For synthesis, see Lit.. ... 

It was believed for a long time that cannabinoids occurred only in hemp, until perrottetinene was discovered in 1994 in the small leafy-stern liverwort (Radula perrottetii). Later, this compound was also found in Radula laxiramea, and along with its carboxylic acid in the New Zealand liverwort (Radula mar-ginata) as well. [119] At the present time, around 70 phytocannabinoids (i.e. plant-derived cannabinoids) are known. 

Bibenzyl cannabinoid. Isol. from the liverwort Radula perrottetii. Oil. [aj —121.3 (c, 0.4 in CHCI3). Similar to A -Tetrahydrocannabinol, T-00398. 

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