Radiosensitization ideal

Biology Complicates the Delivery of Radiation Biology Also Complicates the Delivery of Chemotherapy Principles Guiding the Integration of Chemoradiation Ideal Radiosensitizer ... 

An ideal radiosensitizer would be the one that can maximize radiation therapy benefit, can be easily administered, can be optimally sequenced with radiation therapy for best effects, and have no overlapping toxicities with radiation. Although falling short in certain of these characteristics, 5-fluorouracil (5-FU) has become the most promising clinical radiosensitizer in combined chemoradiotherapy regimens. 

Practically speaking, 5-FU infused at 25-30 mg/kg/d continuously for 5 d will radiosensitize virtually all 5-FU-sensitive tumors listed in Table 1. Although the optimal regimen has yet to be established, the 5-d schedule of 5-FU currently appears close to an ideal regimen. 

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