Radioimaging agents

There are compounds for which standard in vivo tests do not provide additional useful information. This is particularly true for compounds for which data from studies on toxicokinetics or pharmacokinetics indicate that they are not systemically absorbed and therefore are not available for the target tissues. Examples of such compounds are some radioimaging agents, aluminum based antacids, and some dermally applied pharmaceuticals. In those cases other tests, systems should be considered to be more relevant. 

Technetium and rhenium coordination chemistry associated with the introduction of Tc into radiotherapy and radioimaging agents is of active current interest, and the application of nit/o-carbaborane hgands has recently been explored. Microwave heating assists the formation of rhenium jj -carbaborane complexes in aqueous solution, and similar conditions are effective at the tracer level for the preparation of 99mTc complexes. ... 

Altropane and ioflupane bind L-dopamine transporter protein. They are being developed, respectively, as potential contrast agent for radioimaging and imaging... 

---