Radical Fragmentations, Rearrangements and Cyclizations

Useful synthetic methodologies are based on the cyclization, rearrangement, or fragmentation of the alkoxy radicals generated in the reaction of alcohols with [bis(acyloxy)iodo]arenes in the presence of iodine under photochemical conditions or in the absence of irradiation. Photolysis of PhI(OAc)2 with cyclic alcohols in the presence of iodine leads to the generation of the respective alkoxy radical, which can undergo various 

The methodology based on the generation of N-centered radicals from the reaction of amides with iodosyl-benzene and iodine has been utilized in the synthesis of homochiral 7-oxa-2-azabicyclo[2.2.1]heptane 

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