Rabeprazole Antacids

Maalox does not appear to alter the pharmacokinetics of omeprazole, pantoprazole or rabeprazole. Antacids may cause a slight reduction in the bioavailability of lansoprazole. This is probably not clinically relevant but can be accommodated by separating their administration by one hour. There is no interaction between sodium alginate and omeprazole. 

Agents in this class are omeprazole, lansoprazole, pantoprazole and rabeprazole. Esomeprazole is the S-enantiomer of omeprazole. After ingestion of gastric acid resistant formulations they are rapidly and more or less completely absorbed. Bioavailability may be reduced if administered with food or antacids. Elimination is via metabolism in the liver and the renal excretion of inactive metabolites. The elimination half-live is very variable, however, as explained above, not related to the duration of action. 

In a single-dose study, 12 healthy subjects were, on separate occasions, given 20 mg of rabeprazole with, without, and 1-hour after a dose of alu-minium/magnesium hydroxide antacid (Maalox).The antacid had no effect on the pharmacokinetics of rabeprazole, so no speeial precautions would seem necessary on concurrent use. 

Yasuda S, Higashi S, Murakami M, Tomcno Y, Kawaguchi M Antacids have no influence cn the pharmacokinetics of rabeprazole, a new proton pump inhibitor, in healthy volunteera. IntJ Clin Pharmacol Ther (1999) 37,249-53. 

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See also in sourсe #XX -- [ ]

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