Rab protein family

Rab proteins A family of ras-related proteins first observed in rat brain they are GTPases and are active when GTP is found... 

Seel A member of a family of proteins that attach to t-SNAREs and are displaced from them by Rab proteins, thereby allowing v-SNARE-t-SNARE interactions to occur. 

Rab is a family of small G proteins involved in membrane vesicle trafficking. Mammalian tissues contain around 30 forms of Rab, which specifically associate with the various types of membrane vesicles and organelles that exist in cells [30,31]. Rab proteins, named originally as ras-related proteins in brain, are isoprenylated and associate with membranes, as do isoprenylated Ras and G protein y subunits. However, unlike these other G proteins, the GTP and GDP binding to Rab appears to regulate its association with membrane compartments. 

Maridonneau-Parini, I., Yang, C.-Z., Bomens, M., Goud, B. (1991). Increase in the expression of a family of small guanosine triphosphate-binding proteins, rab proteins, during induced phagocyte differentiation. J. Clin. Invest. 87,901-7. 

RabGGTase acts specifically on Rab proteins. The Rab proteins are involved in vesicular transport within the cell, with many of the proteins localized in specific compartments of the secretory and endocytic pathways. The Rab family displays a set of one or two cysteine-containing C-terminal motifs (CC, CXC, CCX, CCXX, CCXXX, CXXX) and is (di) geranylgeranylated by RabGGTase. This is achieved in a ternary complex of... 

Rab proteins exist in all cells and form the largest branch of the Ras superfamily. This family performs a central function in vesicular transport. Rab proteins influence and regulate the budding, targeting, docking and fusion of vesicles as well as processes of exocytosis and endocytosis involving clathrin-coated vesicles. During these functions, Rab proteins cycle between the cytosol and the cell membrane, and this cyle is superimposed on a GDP/GTP cycle. The cytosolic pool of the Rab pro-... 

In general, there are two approaches which have been used to prepare lipidated proteins (1) the incorporation of the lipid by lipid transfer enzymes and (2) the ligation of lipidated peptides with expressed proteins [66]. Recently, approaches using protein prenyltransferases have been used to obtain prenylated Ras family proteins. Protein prenyltransferases can tolerate diverse modifications of their lipid substrates [67, 68]. Therefore, bioorthogonal groups or probes can be incorporated into proteins containing a CaaX motif or Rab proteins via prenylation [69-72]. 

Rab is a family of small G proteins involved in membrane vesicle trafficking 343... 

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