R. Davis and Donald J. Burton

Fluorinated vinylzinc reagents have been prepared by two methods  

Preparation of a fluorovinylzinc reagent by direct metallation of a fluorovinyl halide preparation of 1,2,2-trifluoroethenylzinc bromide4,5 

Caution Carry out all procedures in a well-ventilated hood, and wear disposable vinyl or latex gloves and safety glasses. 

Assemble the apparatus as described above. Maintain a slight positive N2 pressure throughout the course of the reaction. Add the acid washed Zn and DMF to the reaction flask. 

Attach the bromotrifluoroethylene cylinder to the condenser with rubber tubing and condense approx. 20 g 0.1 mol) of the bromotrifluoroethylene into the reaction flask. Stir the mixture at room temperature until the reaction initiates, as evidenced by an exotherm and formation of a dark brown coloured mixture. If initiation does not occur within 1 h at room temperature, warm the flask gently to 50-60°C with a heat gun to initiate metallation. 

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Charles R. Davis and Donald J. Burton Protocol 4. Continued... 

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