Quinoxaline candidates

Vdovina A.L., Thermal Transformations and Stabilization of Polypyromellitimide, Polyphenylquinoxaline and Copolyimidophenyl-quinoxalines , Candidate Dissertation Thesis, Moseow, 1988. (Rus)... 

In the effort to expand the potential chemotherapeutic drug candidates, quinoxalines and related heterocycles were examined. Condensation of the 1,2-diaminobenzene with oxalic acid provides the quinoxaline tautomer in high yields. Treatment of this mixture of tautomers with phosphoryl trichloride provides the multifunctional ring. Displacing a chloride with sodium azide provides the tetrazole, which is considered as a planar acidic analogue of the carboxylic acid functionality. It can increase binding affinity,potency, and bioavailability.Condensation of the hydrazine with benzaldehyde completes these drug candidates. 

---